although - despite 

Although-even though |  Despite - in spite of 
are used to combine or link two contrasting statements.

               Example :

              He had enough money.   He refused to buy a new car.

               1) The above two statements can be combined as follows :

                    ► Although/even though he had enough money, he refused to buy a new car.

                    ► Despite/in spite of having enough money, he refused to buy a new car.

                    ► He had enough money, but despite/in spite of that he refused to buy a new car.

               2)  a) Although/even though are followed by a subject + a verb :

                        - Although it was raining, he walked to the station.      

                    b) Despite/in spite of are followed by a noun, a pronoun or a verb ending in -ing.

                        - In spite of the rain, he walked to the station.
                        - Despite being tired, he walked to the station.

               3)  Despite/in spite of have the same meaning, but despite is used without 'of'.